نتایج جستجو برای: Keywords:Gene expressionHematopoietic stem cellsMethylationTumor suppressor genes
تعداد نتایج: 706243 فیلتر نتایج به سال:
objective(s): stem cell differentiation into different cell lineages depends upon several factors, cell cycle control elements and intracellular signaling elements, including p15ink4b and p16ink4a genes. epigenetics may be regarded as a control mechanism which is affected by these factors with respect to their promoter structure. materials and methods: the cd34 + cord blood stem cells were pu...
Background and Objective: Specific differentiation processes to various cell lineages are closely associated with factors such as transcription factors, tumor suppressor elements and internal signaling pathways including vHL, Ecad, and Runx3. Epigenetics is an effective control mechanism of these factors, including several mechanisms such as methylation and acetylation. The main objective of th...
a member of homeodomain protein namely tgif2lx has been implicated as a tumor suppressor gene in human malignancy as well as in spermatogenesis. however, to our knowledge, dynamic functional evidence of the tgif2lx has not yet been provided. the aim of the present study was to investigate the human tgif2lx target gene(s) using a cdna-aflp as a differential display method. a pegfp-tgif2lx constr...
Developmental genes are silenced in embryonic stem cells by a bivalent histone-based chromatin mark. It has been proposed that this mark also confers a predisposition to aberrant DNA promoter hypermethylation of tumor suppressor genes (TSGs) in cancer. We report here that silencing of a significant proportion of these TSGs in human embryonic and adult stem cells is associated with promoter DNA ...
Background & Aims: The use of siRNA to silence gene expression is increasingly expanding today. The aim of this study is to bioinformatically and experimentally investigate the inhibition of the HMGA2 gene and its corresponding effects on downstream genes expression rate in MDA-MB-231 cancer cell treated by shRNA and siRNA specific to HMGA2. Materials & Methods: To perform this bioinformatic a...
Objective(s): Stem cell differentiation into different cell lineages depends upon several factors, cell cycle control elements and intracellular signaling elements, including P15INK4b and P16INK4a genes. Epigenetics may be regarded as a control mechanism which is affected by these factors with respect to their promoter structure. Materials and Methods: The CD34 + cord blood s...
Epigenetic modification is one of the effective factors in tumorigenesis. Epigenetic processes, especially aberrant DNA methylation, play important role in thyroid cancer, and many tumor suppressor genes including PTEN, RASSF1A and TIMP3 are aberrantly methylated and silenced in thyroid cancer. Because of the specified pattern of DNA methylation in various tumor cells, it is suggested that thes...
Stem cells possess the capacity to expand and self-renew and do so by dividing in either a symmetrical or an asymmetrical manner. Under particular circumstances, some stem cell populations can undergo prolonged cell cycle arrest or quiescence, until they are triggered to divide by a given stimulus. In cancer treatment, these populations represent a significant roadblock to efficient therapies a...
Glioblastoma stem cells (GBM-SCs) are believed to be a subpopulation within all glioblastoma (GBM) cells that are in large part responsible for tumor growth and the high grade of therapeutic resistance that is so characteristic of GBM. MicroRNAs (miR) have been implicated in regulating the expression of oncogenes and tumor suppressor genes in cancer stem cells, including GBM-SCs, and they are a...
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